• Postgraduate Programme (MSc)
  • BECRO

Modified on Saturday, July 18, 2026

CURRICULUM VITAE

Professor Elias Zintzaras

Education

Ph.D. in Bioinformatics, University of Piraeus, Piraeus, Greece.

Ph.D. in Biometry, National Institute for Medical Research, London, UK.

M.Sc. in Biometry, Department of Applied Statistics, University of Reading, UK.

B.Sc. in Mathematics, Department of Mathematics, University of Thessaloniki, Greece.

Current Academic Posts

Professor of Biometry, Director of Laboratory of Biomathematics and MSc in “Biomedical Research Methodology, Biostatistics and Clinical Bioinformatics”, University of Thessaly School of Medicine, Larissa, Greece. Courses: Biostatistics, Bioinformatics and Clinical Trials Methodology.

Adjunct Professor of Medicine, The Institute for Clinical Research and Health Policy Studies and Graduate Program in Pharmacology & Drug Development Program, Tufts University School of Medicine, Boston, MA, USA. Courses: Bioequivalence Testing.

Previous Academic Posts

Researcher in Biometrics-Bioinformatics, Director, Department of Informatics, National Agricultural Research Foundation.

Institute for Cancer Prevention, Harvard School of Public Health, Harvard University, USA>Visiting Scientist.

University of Lisbon, Faculty of Pharmacy, Visiting Lecturer, topic: “Biostatistical Aspects of Bioequivalence Studies”, Spring Semester.

Βiometrician Researcher, Medical Research Council (MRC), National Institute for Medical Research, London, U.K.

Pharmaceutical Oriented Professional Experience

Chairman and Scientific Coordinator, BECRO, Services to Pharmaceutical Industry, Athens, Greece.

Evaluator of Clinical Trials and Bioequivalence Studies, Evaluation Division, Hellenic Organization for Medicines (EOF), Member of the Committee for Bioequivalence testing, Athens, Greece.

External Evaluator of Clinical Trials and Bioequivalence Studies, Hellenic Organization for Medicines (EOF), Athens, Greece.

Biostatistician Expert, European Medicines Agency (ΕΜΑ).

Member of the Biostatistics Working Party, European Medicines Agency (ΕΜΑ).

Professional Training

Medical and Pharmaceutical Statistics Research Unit, The University of Reading, UK, Training on Meta- Analysis of Controlled Clinical Trials.

Medicines Control Agency (now MHRA), London, U.K., Training on the Statistical Evaluation of Bioequivalence studies and Clinical Trials.

The New England Epidemiology Institute, Tufts University, U.S.A., Training on the Statistical Analysis of Ordered Categorical Data, Summer School.

European Course in Advanced Statistics, Sete, France, Training on the Design of Experiments.

Member of Editorial Boards of Scientific Journals

Biomarkers, The Open Medical Informatics Journal, The Open Applied Informatics Journal, The Open Epidemiology Journal, Research Journal of Medical Sciences, BMC-series journals (Statistical Adviser), etc.

Publications of papers in Scientific Journals with Impact Factor

Number > 250, Number of Citations > 15000, h-index: 70

Selected Publications

  • Zintzaras, E. (2012). The power of generalized odds ratio in assessing association in genetic studies with known mode of inheritance. Journal of Applied Statistics, 39(12), 2569–2581. https://doi.org/10.1080/02664763.2012.722611
  • Zintzaras E. The generalized odds ratio as a measure of genetic risk effect in the analysis and meta-analysis of association studies. Stat Appl Genet Mol Biol. 2010;9:Article21. doi: 10.2202/1544-6115.1542. Epub 2010 May 12. PMID: 20597847.
  • Zintzaras E, Santos M. Performance of MAX test and degree of dominance index in predicting the mode of inheritance. Stat Appl Genet Mol Biol. 2012 Jun 27;11(4):Article 4. doi: 10.1515/1544-6115.1804. PMID: 22745022.
  • Zintzaras, E., Santos, M., & Szathmary, E. (n.d.). Monte Carlo simulation models of early key genetic systems.
  • Zintzaras E, Santos M, Szathmary E. "Living" under the challenge of information decay: the stochastic corrector model vs. hypercycles. J Theor Biol. 2002 Jul 21;217(2):167-81. doi: 10.1006/jtbi.2002.3026. PMID: 12202111.
  • Zintzaras E, Kowald A. A mathematical model of HIV dynamics in the presence of a rescuing virus with replication deficiency. Theory Biosci. 2011 Jun;130(2):127-34. doi: 10.1007/s12064-011-0119-y. Epub 2011 Jan 29. PMID: 21279471.
  • Zintzaras E. Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium. Eur J Epidemiol. 2008;23(5):323-6. doi: 10.1007/s10654-008-9242-6. PMID: 18404407.
  • Zintzaras, E., & Ioannidis, J. P. A. (2012). METRADISC-XL: A program for meta-analysis of multidimensional ranked discovery oriented datasets including microarrays. Computer Methods and Programs in Biomedicine, 108(3), 1243–1246. https://doi.org/10.1016/j.cmpb.2012.08.001
  • Zintzaras, E., & Ioannidis, J. P. A. (2008). Meta-analysis for ranked discovery datasets: Theoretical framework and empirical demonstration for microarrays. Computational Biology and Chemistry, 32(1), 39–47. https://doi.org/10.1016/j.compbiolchem.2007.09.003
  • Zintzaras E. The existence of sequence effect in cross-over bioequivalence trials. Eur J Drug Metab Pharmacokinet. 2000 Jul-Dec;25(3-4):241-4. doi: 10.1007/BF03192321. PMID: 11420897.
  • Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 2005 Feb;28(2):123-37. doi: 10.1002/gepi.20048. PMID: 15593093.
  • Zintzaras, E., Brown, N. P., & Kowald, A. (2006). Non-parametric classification of protein secondary structures. Computers in Biology and Medicine, 36(2), 145–156.
  • Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol. 2008 Jul;61(7):634-45. doi: 10.1016/j.jclinepi.2007.12.011. PMID: 18538260.
  • Ioannidis JP, Trikalinos TA, Zintzaras E. Extreme between-study homogeneity in meta-analyses could offer useful insights. J Clin Epidemiol. 2006 Oct;59(10):1023-32. doi: 10.1016/j.jclinepi.2006.02.013. Epub 2006 Aug 7. PMID: 16980141.
  • Zintzaras E, Bouka P. Bioequivalence studies: biometrical concepts of alternative designs and pooled analysis. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):225-32. doi: 10.1007/BF03190024. PMID: 10716060.
  • Zintzaras E, Lau J. Trends in meta-analysis of genetic association studies. J Hum Genet. 2008;53(1):1-9. doi: 10.1007/s10038-007-0223-5. Epub 2007 Dec 12. PMID: 18071627.
  • Kitsios GD, Zintzaras E. Genomic convergence of genome-wide investigations for complex traits. Ann Hum Genet. 2009 Sep;73(Pt 5):514-9. doi: 10.1111/j.1469-1809.2009.00533.x. Epub 2009 Jul 9. PMID: 19604225; PMCID: PMC2971667.
  • Santos M, Zintzaras E, Szathmary E. Recombination in primeval genomes: a step forward but still a long leap from maintaining a sizable genome. J Mol Evol. 2004 Oct;59(4):507-19. doi: 10.1007/s00239-004-2642-7. PMID: 15638462.
  • Zintzaras E, Bouka P, Kowald A. Biometrical evaluation of bioequivalence trials using a bootstrap individual direct curve comparison method. Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):11-6. doi: 10.1007/BF03190400. PMID: 11996322.
  • Santos M, Zintzaras E, Szathmary E. Origin of sex revisited. Orig Life Evol Biosph. 2003 Oct;33(4-5):405-32. doi: 10.1023/a:1025759024888. PMID: 14604184.
  • Zintzaras E. Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis. Eur J Epidemiol. 2010 Aug;25(8):553-60. doi: 10.1007/s10654-010-9467-z. Epub 2010 Jun 5. PMID: 20526652
  • Szathmary E, Zintzaras E. A statistical test of hypotheses on the organization and origin of the genetic code. J Mol Evol. 1992 Sep;35(3):185-9. doi: 10.1007/BF00178593. PMID: 1518086.
  • Zintzaras, E., Bai, M., Douligeris, C., Kowald, A., & Kanavaros, P. (2007). A tree-based decision rule for identifying profile groups of cases without predefined classes: Application in diffuse large B-cell lymphomas. Computers in Biology and Medicine, 37(5), 637–641. https://doi.org/10.1016/j.compbiomed.2006.06.001
  • Zintzaras, E., & Kowald, A. (2010). Forest classification trees and forest support vector machines algorithms: Demonstration using microarray data. Computers in Biology and Medicine, 40(5), 519–524. https://doi.org/10.1016/j.compbiomed.2010.03.006
  • Zintzaras E. Statistical aspects of bioequivalence testing between two medicinal products. Eur J Drug Metab Pharmacokinet. 2005 Jan-Jun;30(1-2):41-6. doi: 10.1007/BF03226406. PMID: 16010860.
  • Zintzaras, E., Santos, M., & Szathmary, E. (2010). Selfishness versus functional cooperation in a stochastic protocell model. Journal of Theoretical Biology, 267(4), 605–613. https://doi.org/10.1016/j.jtbi.2010.09.006
  • Zintzaras, E., Santos, M., & Szathmary, E. (2010). Selfishness versus functional cooperation in a stochastic protocell model. Journal of Theoretical Biology, 267(4), 605–613. https://doi.org/10.1016/j.jtbi.2010.09.011
  • Trikalinos TA, Salanti G, Zintzaras E, Ioannidis JP. Meta-analysis methods. Adv Genet. 2008;60:311-34. doi: 10.1016/S0065-2660(07)00413-0. PMID: 18358326.
  • Zintzaras E, Ioannidis JP. Modelling of escalating outpatient antibiotic expenditures. J Antimicrob Chemother. 2003 Dec;52(6):1001-4. doi: 10.1093/jac/dkg464. Epub 2003 Oct 29. PMID: 14585862.
  • Zintzaras E. Estimating genetic correlations based on phenotypic data: a simulation-based method. J Genet. 2011 Apr;90(1):51-8. doi: 10.1007/s12041-011-0021-x. PMID: 21677389.
  • Zintzaras E, Ioannidis JP. HELOW: a program for testing extreme homogeneity in meta-analysis. Comput Methods Programs Biomed. 2014 Nov;117(2):383-6. doi: 10.1016/j.cmpb.2014.06.009. Epub 2014 Jun 23. PMID: 25023534.
  • Zintzaras, E., & Kowald, A. (1999). A comparison of amino acid distance measures using Procrustes analysis. Computers in Biology and Medicine, 29(5), 283–288. https://doi.org/10.1016/S0010-4825(99)00014-1
  • Zintzaras, E., Brown, N. P., & Kowald, A. (1994). Growing a classification tree using the apparent misclassification rate. Bioinformatics, 10(3), 263–271. https://doi.org/10.1093/bioinformatics/10.3.263
  • Zintzaras E, Santos M. Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index. BMC Med Res Methodol. 2011 Dec 21;11:171. doi: 10.1186/1471-2288-11-171. PMID: 22188898; PMCID: PMC3299619.
  • Zintzaras, E. (2008). Classification tree based protein structure distances for testing sequence–structure correlation. Computers in Biology and Medicine, 38(4), 469–474. https://doi.org/10.1016/j.compbiomed.2008.01.006
  • Zintzaras, E. (2013). Examining the stability of genetic risk effect as evidence accumulates in the context of meta-analysis. Computers in Biology and Medicine, 43(9), 1293–1299. https://doi.org/10.1016/j.compbiomed.2013.04.017
  • Zintzaras E, Ioannidis JP. HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics. 2005 Sep 15;21(18):3672-3. doi: 10.1093/bioinformatics/bti536. Epub 2005 Jun 14. PMID: 15955784.
  • Kitsios GD, Zintzaras E. Genome-wide association studies: hypothesis-"free" or "engaged"? Transl Res. 2009 Oct;154(4):161-4. doi: 10.1016/j.trsl.2009.07.001. Epub 2009 Jul 29. PMID: 19766959; PMCID: PMC2971665.