• Πρόγραμμα Μεταπτυχιακών Σπουδών (ΠΜΣ)
  • BECRO

Τροποποιήθηκε Τρίτη, 3 Νοεμβρίου 2026

 Selected Publications

  • Zintzaras, E. (2012). The power of generalized odds ratio in assessing association in genetic studies with known mode of inheritance. Journal of Applied Statistics, 39(12), 2569–2581. https://doi.org/10.1080/02664763.2012.722611
  • Zintzaras E. The generalized odds ratio as a measure of genetic risk effect in the analysis and meta-analysis of association studies. Stat Appl Genet Mol Biol. 2010;9:Article21. doi: 10.2202/1544-6115.1542. Epub 2010 May 12. PMID: 20597847.
  • Zintzaras E, Santos M. Performance of MAX test and degree of dominance index in predicting the mode of inheritance. Stat Appl Genet Mol Biol. 2012 Jun 27;11(4):Article 4. doi: 10.1515/1544-6115.1804. PMID: 22745022.
  • Zintzaras, E., Santos, M., & Szathmary, E. (n.d.). Monte Carlo simulation models of early key genetic systems.
  • Zintzaras E, Santos M, Szathmary E. "Living" under the challenge of information decay: the stochastic corrector model vs. hypercycles. J Theor Biol. 2002 Jul 21;217(2):167-81. doi: 10.1006/jtbi.2002.3026. PMID: 12202111.
  • Zintzaras E, Kowald A. A mathematical model of HIV dynamics in the presence of a rescuing virus with replication deficiency. Theory Biosci. 2011 Jun;130(2):127-34. doi: 10.1007/s12064-011-0119-y. Epub 2011 Jan 29. PMID: 21279471.
  • Zintzaras E. Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium. Eur J Epidemiol. 2008;23(5):323-6. doi: 10.1007/s10654-008-9242-6. PMID: 18404407.
  • Zintzaras, E., & Ioannidis, J. P. A. (2012). METRADISC-XL: A program for meta-analysis of multidimensional ranked discovery oriented datasets including microarrays. Computer Methods and Programs in Biomedicine, 108(3), 1243–1246. https://doi.org/10.1016/j.cmpb.2012.08.001
  • Zintzaras, E., & Ioannidis, J. P. A. (2008). Meta-analysis for ranked discovery datasets: Theoretical framework and empirical demonstration for microarrays. Computational Biology and Chemistry, 32(1), 39–47. https://doi.org/10.1016/j.compbiolchem.2007.09.003
  • Zintzaras E. The existence of sequence effect in cross-over bioequivalence trials. Eur J Drug Metab Pharmacokinet. 2000 Jul-Dec;25(3-4):241-4. doi: 10.1007/BF03192321. PMID: 11420897.
  • Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 2005 Feb;28(2):123-37. doi: 10.1002/gepi.20048. PMID: 15593093.
  • Zintzaras, E., Brown, N. P., & Kowald, A. (2006). Non-parametric classification of protein secondary structures. Computers in Biology and Medicine, 36(2), 145–156.
  • Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol. 2008 Jul;61(7):634-45. doi: 10.1016/j.jclinepi.2007.12.011. PMID: 18538260.
  • Ioannidis JP, Trikalinos TA, Zintzaras E. Extreme between-study homogeneity in meta-analyses could offer useful insights. J Clin Epidemiol. 2006 Oct;59(10):1023-32. doi: 10.1016/j.jclinepi.2006.02.013. Epub 2006 Aug 7. PMID: 16980141.
  • Zintzaras E, Bouka P. Bioequivalence studies: biometrical concepts of alternative designs and pooled analysis. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):225-32. doi: 10.1007/BF03190024. PMID: 10716060.
  • Zintzaras E, Lau J. Trends in meta-analysis of genetic association studies. J Hum Genet. 2008;53(1):1-9. doi: 10.1007/s10038-007-0223-5. Epub 2007 Dec 12. PMID: 18071627.
  • Kitsios GD, Zintzaras E. Genomic convergence of genome-wide investigations for complex traits. Ann Hum Genet. 2009 Sep;73(Pt 5):514-9. doi: 10.1111/j.1469-1809.2009.00533.x. Epub 2009 Jul 9. PMID: 19604225; PMCID: PMC2971667.
  • Santos M, Zintzaras E, Szathmary E. Recombination in primeval genomes: a step forward but still a long leap from maintaining a sizable genome. J Mol Evol. 2004 Oct;59(4):507-19. doi: 10.1007/s00239-004-2642-7. PMID: 15638462.
  • Zintzaras E, Bouka P, Kowald A. Biometrical evaluation of bioequivalence trials using a bootstrap individual direct curve comparison method. Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):11-6. doi: 10.1007/BF03190400. PMID: 11996322.
  • Santos M, Zintzaras E, Szathmary E. Origin of sex revisited. Orig Life Evol Biosph. 2003 Oct;33(4-5):405-32. doi: 10.1023/a:1025759024888. PMID: 14604184.
  • Zintzaras E. Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis. Eur J Epidemiol. 2010 Aug;25(8):553-60. doi: 10.1007/s10654-010-9467-z. Epub 2010 Jun 5. PMID: 20526652
  • Szathmary E, Zintzaras E. A statistical test of hypotheses on the organization and origin of the genetic code. J Mol Evol. 1992 Sep;35(3):185-9. doi: 10.1007/BF00178593. PMID: 1518086.
  • Zintzaras, E., Bai, M., Douligeris, C., Kowald, A., & Kanavaros, P. (2007). A tree-based decision rule for identifying profile groups of cases without predefined classes: Application in diffuse large B-cell lymphomas. Computers in Biology and Medicine, 37(5), 637–641. https://doi.org/10.1016/j.compbiomed.2006.06.001
  • Zintzaras, E., & Kowald, A. (2010). Forest classification trees and forest support vector machines algorithms: Demonstration using microarray data. Computers in Biology and Medicine, 40(5), 519–524. https://doi.org/10.1016/j.compbiomed.2010.03.006
  • Zintzaras E. Statistical aspects of bioequivalence testing between two medicinal products. Eur J Drug Metab Pharmacokinet. 2005 Jan-Jun;30(1-2):41-6. doi: 10.1007/BF03226406. PMID: 16010860.
  • Zintzaras, E., Santos, M., & Szathmary, E. (2010). Selfishness versus functional cooperation in a stochastic protocell model. Journal of Theoretical Biology, 267(4), 605–613. https://doi.org/10.1016/j.jtbi.2010.09.006
  • Zintzaras, E., Santos, M., & Szathmary, E. (2010). Selfishness versus functional cooperation in a stochastic protocell model. Journal of Theoretical Biology, 267(4), 605–613. https://doi.org/10.1016/j.jtbi.2010.09.011
  • Trikalinos TA, Salanti G, Zintzaras E, Ioannidis JP. Meta-analysis methods. Adv Genet. 2008;60:311-34. doi: 10.1016/S0065-2660(07)00413-0. PMID: 18358326.
  • Zintzaras E, Ioannidis JP. Modelling of escalating outpatient antibiotic expenditures. J Antimicrob Chemother. 2003 Dec;52(6):1001-4. doi: 10.1093/jac/dkg464. Epub 2003 Oct 29. PMID: 14585862.
  • Zintzaras E. Estimating genetic correlations based on phenotypic data: a simulation-based method. J Genet. 2011 Apr;90(1):51-8. doi: 10.1007/s12041-011-0021-x. PMID: 21677389.
  • Zintzaras E, Ioannidis JP. HELOW: a program for testing extreme homogeneity in meta-analysis. Comput Methods Programs Biomed. 2014 Nov;117(2):383-6. doi: 10.1016/j.cmpb.2014.06.009. Epub 2014 Jun 23. PMID: 25023534.
  • Zintzaras, E., & Kowald, A. (1999). A comparison of amino acid distance measures using Procrustes analysis. Computers in Biology and Medicine, 29(5), 283–288. https://doi.org/10.1016/S0010-4825(99)00014-1
  • Zintzaras, E., Brown, N. P., & Kowald, A. (1994). Growing a classification tree using the apparent misclassification rate. Bioinformatics, 10(3), 263–271. https://doi.org/10.1093/bioinformatics/10.3.263
  • Zintzaras E, Santos M. Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index. BMC Med Res Methodol. 2011 Dec 21;11:171. doi: 10.1186/1471-2288-11-171. PMID: 22188898; PMCID: PMC3299619.
  • Zintzaras, E. (2008). Classification tree based protein structure distances for testing sequence–structure correlation. Computers in Biology and Medicine, 38(4), 469–474. https://doi.org/10.1016/j.compbiomed.2008.01.006
  • Zintzaras, E. (2013). Examining the stability of genetic risk effect as evidence accumulates in the context of meta-analysis. Computers in Biology and Medicine, 43(9), 1293–1299. https://doi.org/10.1016/j.compbiomed.2013.04.017
  • Zintzaras E, Ioannidis JP. HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics. 2005 Sep 15;21(18):3672-3. doi: 10.1093/bioinformatics/bti536. Epub 2005 Jun 14. PMID: 15955784.
  • Kitsios GD, Zintzaras E. Genome-wide association studies: hypothesis-"free" or "engaged"? Transl Res. 2009 Oct;154(4):161-4. doi: 10.1016/j.trsl.2009.07.001. Epub 2009 Jul 29. PMID: 19766959; PMCID: PMC2971665.